Why does Benadryl get me up


  • Generic name: Diphenhydramine
  • Brand Name: Benadryl
Benadryl Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What is Benadryl?

Benadryl (diphenhydramine) is an antihistamine used to treat allergies, hives, insomnia, motion sickness, and mild cases of Parkinson's. Benadryl is available in generic form and over-the-counter (OTC).

What are the side effects of Benadryl?

Common side effects of Benadryl include:

  • Sleepiness,
  • fatigue,
  • Fatigue,
  • Sleepiness,
  • Dizziness,
  • impaired coordination,
  • Constipation,
  • dry mouth / nose / throat,
  • Difficulty urinating or an enlarged prostate,
  • Upset stomach,
  • blurred vision,
  • Double vision,
  • Tremor,
  • Loss of appetite,
  • Headache or
  • Nausea.

Dosage for Benadryl

A typical dose of Benadryl is 25-50 mg every 4-6 hours.

Which drugs, substances or dietary supplements interact with Benadryl?

Benadryl may interact with monoamine oxidase inhibitors (MAOIs), other over-the-counter cough, cold, allergy, or insomnia medicines, anxiety or sleep medications, antidepressants, or any other medication that may make you drowsy, drowsy, or relaxed. Let your doctor know about all medications and supplements you use.

Benadryl during pregnancy and breastfeeding

Benadryl has not been adequately rated in pregnant women. Benadryl is excreted in breast milk. Because of the risk of stimulation and seizures in infants, especially newborns and premature babies, antihistamines should not be used by nursing mothers.

additional information

Our Benadryl Side Effects Drug Center provides a comprehensive overview of the drug information available about the possible side effects of taking this drug.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Side effects of Onglyza 5 mg
Benadryl consumer information

Get emergency medical help if you have Signs of an allergic reaction : Beehives; Difficulty breathing; Swelling of the face, lips, tongue, or throat.

Stop using diphenhydramine and call your doctor right away if you:

  • Heartbeats beating or fluttering in your chest;
  • painful or difficult urination;
  • little or no urination;
  • Confusion, feeling passed out; or
  • Tightness in the neck or jaw, uncontrollable movements of the tongue.

Common side effects can include:

  • Dizziness, drowsiness, loss of coordination;
  • dry mouth, nose, or throat;
  • Constipation, upset stomach;
  • dry eyes, blurred vision; or
  • Daytime sleepiness or hangover after nocturnal use.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You can report side effects to the FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Benadryl (Diphenhydramine)

Find out more 'Benadryl Professional Information


When using this product:

  • There may be significant drowsiness
  • Avoid alcoholic beverages
  • Alcohol, sedatives, and tranquilizers can make you feel drowsy
  • Excitability can occur especially in children
  • Use caution when driving a motor vehicle or using machines

Read full FDA Prescribing Information for Benadryl (Diphenhydramine)

Read more '' Related Resources for Benadryl

Related health

  • Allergy (allergies)
  • Side effects of medication
  • eczema
  • Hives (urticaria & angioedema)
  • Itching (itching or pruritus)
  • Parkinson's disease
  • Scabies (mites)
  • Sleep disorders (how to sleep well)

Related drugs

Read the Benadryl User Reviews »

Benadryl patient information is provided by Cerner Multum, Inc. and Benadryl consumer information is provided by First Databank, Inc., all of which are used under license and are subject to their respective copyrights.